abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...

journal_title：Cells

authors： Zheng F,Phelan KD

更新日期：2014-04-09 00:00:00

abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...

journal_title：Cells

authors： Chen X,Egly C,Riley AM,Li W,Tewson P,Hughes TE,Quinn AM,Obukhov AG

更新日期：2014-04-04 00:00:00

abstract：:Lyme Borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi that is transmitted through the bite of infected ticks. Both B cell-mediated humoral immunity and T cell immunity develop during natural Borrelia infection. However, compared with humoral immunity, the T cell response to Borrelia i...

journal_title：Cells

authors： Jin C,Roen DR,Lehmann PV,Kellermann GH

更新日期：2013-09-13 00:00:00

abstract：:Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) represent important ...

journal_title：Cells

authors： Wali JA,Masters SL,Thomas HE

更新日期：2013-04-26 00:00:00

abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...

journal_title：Cells

authors： Berthelet J,Dubrez L

更新日期：2013-03-14 00:00:00

abstract：:Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Du...

journal_title：Cells

authors： Lee JE,Cranna NJ,Chahal AS,Quinn LM

更新日期：2012-12-05 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...

journal_title：Cells

authors： Holmberg Olausson K,Nistér M,Lindström MS

更新日期：2012-10-15 00:00:00

abstract：:All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy. Autophagy is a cellular process by which cytoplasmic material is either degraded to...

journal_title：Cells

authors： Kumar P,Zhang DM,Degenhardt K,Chen ZS

更新日期：2012-08-23 00:00:00

abstract：:Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, ...

journal_title：Cells

authors： Brennand A,Rico E,Michels PA

更新日期：2012-07-27 00:00:00

abstract：:In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatric diseases, where study subjects are almost exclusively children...

journal_title：Cells

authors： Faresjö M

更新日期：2012-05-29 00:00:00

abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...

journal_title：Cells

authors： Bonsignori M,Moody MA

更新日期：2012-03-21 00:00:00